The mechanism of the drug interactions may be due to how CBD affects certain CYP metabolizing enzymes in the body. Studies have shown that CBD can inhibit CYP 2C19 and CYP 3A, two major metabolizing enzymes in the body.
Most people can avoid these side effects by following some of the advice listed above — such as drinking plenty of water, taking CBD with food, combining other supplements like caffeine, or limiting the dose of CBD. CBD has been proven to be a safe and effective compound in animal and human clinical trials many times over. hemp oil for face The side effects this compound is most likely to cause are very mild in nature — such as dry mouth, mild drops in blood pressure, diarrhea, loss of appetite, and fatigue, or drowsiness. If you suffer from any liver disorders (hepatitis, fatty liver disease, cirrhosis, etc.), it’s wise to speak with your doctor before using CBD.
Treating chronic pain and other medical conditions with THC and CBD oil specifically represents one of the hottest and most controversial topics in the medical field. There haven’t yet been studies focusing on potential interactions between CBD and antibiotics in particular, but studies suggest that interactions with other types of drugs are possible. For example, it seems that CBD can impact the effects of chemotherapy and epilepsy medications. In these cases, a patient might need their doctor to change the dosage of their medication. If you are already using CBD, or wondering whether it’s right for you, talk to your doctor about the potential for interactions with prescription drugs.
On the contrary, CYP450 inhibitors can increase effects of drugs and medical marijuana by inhibiting the enzymes and slowing down drug metabolism leading to increased concentrations. For example, CBD is a CYP3A4 inhibitor which can lead to potentiated effects of medications such as macrolides, calcium channel blockers, benzodiazepines and antihistamines.
Other effects found to occur very commonly in treated patients in CBD studies for Lennox-Gastaut or Dravet syndrome were vomiting, pyrexia and fatigue. CBD not only affects the central nervous system, but also the cardiovascular system.
The amount of CBD absorbed into the bloodstream topically is likely negligible, making it one of the safest options if you want to use CBD but don’t want it to interact with a more important prescription medication you’re taking. This is just one of the reasons you want to speak with a certified health professional if you’re taking other medication to make sure it doesn’t interfere with a daily serving or more of cannabidiol.
Despite that, combining different drugs or substances can have unpredictable effects on any kind of patient. Propranolol and verapamil, beta blockers that are used to treat blood pressure, atrial fibrillation, and angina, utilize the p450 pathway to be metabolized and used. Cannabidiol can change the way that these prescriptions work, and should not be used in conjunction with CBD oil unless expressly approved by a doctor. Some medications that relieve the symptoms of asthma also rely on the same p450 pathways that CBD oil does, including theophylline. If you take medications for asthma, you should check with your doctor before adding CBD oil.
It is also important to note that THC/CBD ratios vary in each strain profile. Different amounts of cannabinoids and terpenes in your CBD oil can influence its effects.